Anti-fibrinolytic agents in post partum haemorrhage: a systematic review

Anti-fibrinolytic agents in post partum haemorrhage: a systematic review

BACKGROUND Post partum haemorrhage is a leading cause of maternal death worldwide. It also contributes to maternal morbidity as women may require a hysterectomy to control bleeding, or may require a blood transfusion, which can transmit viral infections. Anti-fibrinolytic agents have been proposed as a treatment for post partum haemorrhage. We conducted a systematic review to assess the effecti...

Post-Partum Haemorrhage.

Post-partum haemorrhage is defined as being "excessive bleeding from any part of the genital tract after the birth of a child." Some authorities make a hair-splitting definition and describe intra-partum haemorrhage when excessive bleeding occurs before the placenta has been delivered, and confine the term post-partum haemorrhage to excessive bleeding after the completion of the third stage of ...

Management of post-partum haemorrhage.

Management of post-partum haemorrhage (PPH) involves the treatment of uterine atony, evacuation of retained placenta or placental fragments, surgery due to uterine or birth canal trauma, balloon tamponade, effective volume replacement and transfusion therapy, and occasionally, selective arterial embolization. This article aims at introducing pregnancy- and haemorrhage-induced changes in coagula...

Post-partum haemorrhage and the WOMAN trial.

Post-partum haemorrhage (PPH) is a leading cause of maternal mortality, accounting for about 100 000 maternal deaths every year. Almost all (99%) of the deaths are in low and middle income countries and most of the deaths occur in the immediate post-partum period. There are known effective treatments for preventing severe bleeding after childbirth and it is essential to ensure that all pregnant...

The prevention of post-partum haemorrhage; a re-appraisal.